OR4S1

Across TCGA cell cohorts, OR4S1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible OR4S1-associated genes across cancer lineages are DNASE1L3, SIGLEC8, and KCNJ18. Each is linked with OR4S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4S1-to-partner and partner-to-OR4S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNASE1L3 grouped by OR4S1-low versus OR4S1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4S1→partner) and Y-score (partner→OR4S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DNASE1L3 →	+0.121	+3.946	<.001	.002	3	2
LUNG_SCLC	SIGLEC8 →	+0.004	+3.232	<.001	.008	3	1
LUNG_SCLC	KCNJ18 →	+0.051	+4.058	.003	.001	3	1
LARGE_INTESTINE	MAGEB4 →	+0.019	+5.000	<.001	<.001	3	1
LARGE_INTESTINE	SPINK9 →	+0.323	+3.793	<.001	.007	3	1
OVARY	KRT28 →	+0.065	+4.029	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

DNASE1L3 by OR4S1 expression — LUNG_SCLC

Explore this box plot interactively →