OR4M1

Across TCGA patient cohorts, OR4M1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4M1-associated genes across cancer lineages are MYH11, MEK1, and GAPDH. Each is linked with OR4M1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4M1-to-partner and partner-to-OR4M1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH11 grouped by OR4M1-low versus OR4M1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4M1→partner) and Y-score (partner→OR4M1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MYH11 →	-0.971	-3.000	.017	.033	3	2
UCEC	MEK1 →	+0.514	+2.584	.002	.011	3	2
SKCM	GAPDH →	+0.559	+3.459	.009	.004	3	1
SKCM	HER3 →	+0.340	+1.519	.024	.017	3	1
SKCM	Bim →	-0.228	-2.321	.019	.032	3	1
UCEC	eIF4E →	+0.310	+3.700	.001	.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MYH11 by OR4M1 expression — LUSC

Explore this box plot interactively →