OR4M1

Across TCGA pan-cancer cohorts, OR4M1 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated OR4M1 data layer compared with 5 for mutation status.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher OR4M1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OR4M1 expression acts as an unfavorable survival marker, although some lineages such as ESCA show a favorable association.

CHOL, SKCM, and OV are the cancer types where OR4M1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	OS	Tertile	All	0.024	0.728	<.001	108	view →
SKCM	DFS	Tertile	III,IV	0.310	0.624	.011	36	view →
OV	OS	Tertile	IV	0.170	0.758	.044	18	view →
COAD	OS	Tertile	II,III,IV	0.117	0.788	.001	18	view →
ESCA	OS	Tertile	III,IV	1.000	0.372	.035	12	view →
GBM	OS	Tertile	All	0.197	0.428	.027	9	view →
STAD	DFS	Tertile	IV	0.141	0.539	.049	9	view →
PCPG	DFS	Tertile	All	0.161	0.819	.011	9	view →
BLCA	DFS	Tertile	III,IV	0.130	0.322	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

OR4M1–CHOL (OS)

Open the CHOL breakdown →