OR4K5

Across TCGA patient cohorts, OR4K5 mutation is significantly associated with the RNA expression of many other genes, with 1,080 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4K5-associated genes across cancer lineages are ZYXP1, PANK4, and PEF1. Each is linked with OR4K5 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4K5-to-partner and partner-to-OR4K5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZYXP1 grouped by OR4K5-low versus OR4K5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4K5→partner) and Y-score (partner→OR4K5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ZYXP1 →	+0.198	+7.640	<.001	.009	3	2
UCEC	PANK4 →	+0.383	+3.512	.002	.002	3	2
UCEC	PEF1 →	+0.293	+2.765	.008	.002	3	2
UCEC	FBXO33 →	+0.450	+3.732	.002	<.001	3	2
UCEC	TIMM22 →	+0.502	+3.301	<.001	<.001	3	2
UCEC	DDX10 →	+0.434	+2.098	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,080 associations by consensus.

ZYXP1 by OR4K5 expression — BLCA

Explore this box plot interactively →