OR4K5

Across TCGA patient cohorts, OR4K5 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4K5-associated genes across cancer lineages are MEK1, GAPDH, and PR. Each is linked with OR4K5 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR4K5-to-partner and partner-to-OR4K5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by OR4K5-low versus OR4K5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4K5→partner) and Y-score (partner→OR4K5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.407	+3.584	.010	.002	3	3
SKCM	GAPDH →	+0.535	+2.459	.012	.018	3	2
SKCM	PR →	-0.069	-1.894	.038	.014	3	2
UCEC	eIF4E →	+0.192	+2.115	.037	.019	3	2
UCEC	Rab11 →	-0.132	-2.999	.036	.035	3	2
UCEC	VHL →	-1.370	-3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

MEK1 by OR4K5 expression — UCEC

Explore this box plot interactively →