OR4K5

Across TCGA cell cohorts, OR4K5 mutation is significantly associated with the drug of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR4K5-associated genes across cancer lineages are Fulvestrant, WYE-125132, and CD532. Each is linked with OR4K5 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4K5-to-partner and partner-to-OR4K5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fulvestrant grouped by OR4K5-low versus OR4K5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4K5→partner) and Y-score (partner→OR4K5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Fulvestrant →	+0.436	+2.649	.010	.046	3	1
LARGE_INTESTINE	WYE-125132 →	+0.724	+2.652	.003	.045	3	1
LARGE_INTESTINE	CD532 →	+0.444	+2.652	.027	.045	3	1
LUNG_NSCLC_LUAD	OSI-027 →	+0.527	+2.681	.039	.048	3	1
LARGE_INTESTINE	AZD5991 →	+1.035	+2.649	.006	.046	2	1
LARGE_INTESTINE	Nelarabine →	+0.272	+2.649	.039	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Fulvestrant by OR4K5 expression — LARGE_INTESTINE

Explore this box plot interactively →