OR4K2

Across TCGA cell cohorts, OR4K2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible OR4K2-associated genes across cancer lineages are BPIFB6, OR51G2, and ADIG. Each is linked with OR4K2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4K2-to-partner and partner-to-OR4K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by OR4K2-low versus OR4K2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4K2→partner) and Y-score (partner→OR4K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BPIFB6 →	+0.031	+3.969	<.001	.009	3	1
BLOOD_Leukemia	OR51G2 →	+0.014	+3.969	<.001	.009	3	1
BLOOD_Leukemia	ADIG →	+0.015	+4.569	<.001	.003	3	1
BLOOD_Leukemia	MFRP →	+0.079	+3.149	.004	.009	3	1
SKIN	TBX22 →	+0.123	+3.451	.002	.008	3	1
SKIN	CLEC20A →	+0.015	+2.933	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

BPIFB6 by OR4K2 expression — BLOOD_Leukemia

Explore this box plot interactively →