OR4K17

Across TCGA patient cohorts, OR4K17 mutation is significantly associated with the RNA expression of many other genes, with 1,352 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4K17-associated genes across cancer lineages are OIP5, EME1, and PLK1. Each is linked with OR4K17 in more than 3 cancer types. Because this analysis shows association rather than direction, both OR4K17-to-partner and partner-to-OR4K17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OIP5 grouped by OR4K17-low versus OR4K17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4K17→partner) and Y-score (partner→OR4K17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OIP5 →	+0.887	+3.716	.001	<.001	3	4
UCEC	EME1 →	+0.848	+3.917	<.001	<.001	3	3
UCEC	PLK1 →	+0.764	+2.807	.006	.003	3	3
UCEC	LDLRAD4 →	-0.587	-2.700	.003	.006	3	3
UCEC	PPIH →	+0.428	+3.338	.006	.005	3	3
UCEC	DBNDD1 →	+0.657	+2.807	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,352 associations by consensus.

OIP5 by OR4K17 expression — UCEC

Explore this box plot interactively →