OR4K15

Across TCGA cell cohorts, OR4K15 mutation is significantly associated with the mutation status of many other genes, with 1,047 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR4K15-associated genes across cancer lineages are ACVR2B, NLRP5, and TRPC3. Each is linked with OR4K15 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR4K15-to-partner and partner-to-OR4K15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVR2B grouped by OR4K15-low versus OR4K15-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4K15→partner) and Y-score (partner→OR4K15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ACVR2B →	+5.053	+4.239	.007	.007	1	3
CNS	NLRP5 →	+4.044	+5.000	.008	.008	1	3
LUNG_SCLC	TRPC3 →	+3.722	+4.022	.003	.003	1	2
LARGE_INTESTINE	MAPKAPK5 →	+2.893	+3.222	.003	.003	1	2
SKIN	HTRA3 →	+5.053	+4.239	.007	.007	1	2
SKIN	PDE7B →	+5.638	+4.977	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,047 associations by consensus.

ACVR2B by OR4K15 expression — SKIN

Explore this box plot interactively →