Across TCGA pan-cancer cohorts, OR4K14 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of OR4K14’s most consistent transcriptional readouts.
The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where OR4K14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR4K14 is over-expressed in tumor.
PAAD are the cancer types where OR4K14 tumor–normal differential expression is most reproducible.