OR4K1

Across TCGA patient cohorts, OR4K1 mutation is significantly associated with the RNA expression of many other genes, with 2,810 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4K1-associated genes across cancer lineages are SUPV3L1, SKA3, and RRM2. Each is linked with OR4K1 in more than 3 cancer types. Because this analysis shows association rather than direction, both OR4K1-to-partner and partner-to-OR4K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUPV3L1 grouped by OR4K1-low versus OR4K1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4K1→partner) and Y-score (partner→OR4K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SUPV3L1 →	+0.460	+2.332	.001	.003	3	3
UCEC	SKA3 →	+0.663	+2.343	.002	.003	3	3
UCEC	RRM2 →	+0.749	+2.321	.008	.006	3	3
UCEC	FAM136A →	+0.539	+3.595	<.001	.001	3	3
UCEC	MCM10 →	+0.700	+3.831	.006	<.001	3	3
UCEC	C9orf40 →	+0.608	+3.491	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,810 associations by consensus.

SUPV3L1 by OR4K1 expression — UCEC

Explore this box plot interactively →