Across TCGA patient cohorts, OR4E2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4E2-associated genes across cancer lineages are S6_pS240_S244, Tuberin, and Chk2. Each is linked with OR4E2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4E2-to-partner and partner-to-OR4E2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4E2→partner) and Y-score (partner→OR4E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.474	+3.000	.043	.037	3	1
UCEC	Tuberin →	+0.390	+2.817	.012	.036	3	1
UCEC	Chk2 →	-0.341	-3.000	.011	.037	3	1
SKCM	N-Ras →	+0.122	+1.222	.005	.033	3	1
SKCM	Annexin_VII →	+0.120	+1.906	.013	.014	3	1
SKCM	TFRC →	-0.387	-1.716	.032	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

OR4E2 survival (RNA) · tumor vs normal (RNA) · all OR4E2 data types