OR4D9

Across TCGA patient cohorts, OR4D9 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR4D9-associated genes across cancer lineages are GSK3-a-b, Beclin, and GATA3. Each is linked with OR4D9 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4D9-to-partner and partner-to-OR4D9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK3-a-b grouped by OR4D9-low versus OR4D9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4D9→partner) and Y-score (partner→OR4D9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GSK3-a-b →	-0.328	-3.169	<.001	.018	3	2
SKCM	Beclin →	+0.181	+2.321	.024	.035	3	2
SKCM	GATA3 →	-0.296	-2.982	.001	.034	3	1
SKCM	Rictor_pT1135 →	+0.193	+2.832	.012	.034	3	1
SKCM	YB-1 →	-0.228	-2.321	.025	.035	3	1
SKCM	Chk2_pT68 →	+0.206	+3.012	.008	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

GSK3-a-b by OR4D9 expression — SKCM

Explore this box plot interactively →