OR4D2

Across TCGA patient cohorts, OR4D2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4D2-associated genes across cancer lineages are STAT3_pY705, C-Raf, and p38-MAPK_pT180_Y182. Each is linked with OR4D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4D2-to-partner and partner-to-OR4D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by OR4D2-low versus OR4D2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4D2→partner) and Y-score (partner→OR4D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.373	-2.999	.003	.035	3	2
UCEC	C-Raf →	+0.219	+3.584	.001	.002	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.367	-2.305	.012	.032	3	2
UCEC	mTOR_pS2448 →	-0.208	-2.980	.003	.036	3	1
UCEC	p62 Lck ligand →	+0.386	+3.009	.013	.019	3	1
UCEC	VEGFR2 →	+0.296	+2.179	.039	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

STAT3_pY705 by OR4D2 expression — UCEC

Explore this box plot interactively →