OR4D2

Across TCGA pan-cancer cohorts, OR4D2 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated OR4D2 data layer compared with 7 for mutation status.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher OR4D2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OR4D2 expression acts as an unfavorable survival marker, although some lineages such as OV and ESCA show a favorable association.

PAAD, READ, and KIRC are the cancer types where OR4D2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	DFS	Tertile	All	0.006	0.505	<.001	45	view →
READ	DFS	Tertile	IV	0.027	0.636	<.001	45	view →
KIRC	DFS	Tertile	IV	0.204	0.623	.011	36	view →
BLCA	OS	Tertile	All	0.204	0.687	.028	18	view →
SCLC	DFS	Tertile	All	0.164	0.573	.009	18	view →
OV	DFS	Tertile	IV	0.721	0.239	.044	18	view →
STAD	DFS	Tertile	All	0.501	0.725	.032	12	view →
LUSC	DFS	Tertile	II,III,IV	0.127	0.674	<.001	9	view →
LIHC	DFS	Tertile	All	0.097	0.553	.038	9	view →
LUAD	OS	Tertile	II,III,IV	0.236	0.709	.034	9	view →
ESCA	DFS	Tertile	All	0.579	0.336	.046	6	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.280	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

OR4D2–PAAD (DFS)

Open the PAAD breakdown →