OR4C6

Across TCGA patient cohorts, OR4C6 mutation is significantly associated with the RNA expression of many other genes, with 3,076 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4C6-associated genes across cancer lineages are NIF3L1, GPN3, and DPY30. Each is linked with OR4C6 in more than 3 cancer types. Because this analysis shows association rather than direction, both OR4C6-to-partner and partner-to-OR4C6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NIF3L1 grouped by OR4C6-low versus OR4C6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4C6→partner) and Y-score (partner→OR4C6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NIF3L1 →	+0.429	+2.447	.009	.001	3	4
UCEC	GPN3 →	+0.646	+4.223	<.001	<.001	3	4
LUAD	DPY30 →	+0.461	+3.333	<.001	<.001	3	4
UCEC	VAPA →	+0.399	+2.436	.008	.002	3	4
UCEC	GPI →	+0.456	+3.609	.008	.001	3	4
UCEC	RITA1 →	+0.441	+1.971	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,076 associations by consensus.

NIF3L1 by OR4C6 expression — UCEC

Explore this box plot interactively →