OR4C6

Across TCGA patient cohorts, OR4C6 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4C6-associated genes across cancer lineages are Annexin-1, Di-Ras3, and 4E-BP1. Each is linked with OR4C6 in more than 3 cancer types. Because this analysis shows association rather than direction, both OR4C6-to-partner and partner-to-OR4C6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by OR4C6-low versus OR4C6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4C6→partner) and Y-score (partner→OR4C6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.497	+3.341	.022	.005	3	4
LUSC	Di-Ras3 →	-0.079	-1.860	.024	.049	3	3
UCEC	4E-BP1 →	+0.342	+3.351	.002	.005	2	4
UCEC	PCNA →	+0.294	+2.321	<.001	.006	3	2
UCEC	GAPDH →	+0.457	+2.999	.039	.035	3	2
LUSC	Rad50 →	+0.094	+2.349	.047	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Annexin-1 by OR4C6 expression — UCEC

Explore this box plot interactively →