OR4C45

Across TCGA patient cohorts, OR4C45 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible OR4C45-associated genes across cancer lineages are ANXA13, ANKRD30A, and OR7G2. Each is linked with OR4C45 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4C45-to-partner and partner-to-OR4C45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANXA13 grouped by OR4C45-low versus OR4C45-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4C45→partner) and Y-score (partner→OR4C45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	ANXA13 →	+1.118	+3.321	<.001	.008	3	1
SCLC	ANKRD30A →	+0.016	+3.564	.002	.004	3	1
SCLC	OR7G2 →	+0.084	+3.564	<.001	.004	3	1
SCLC	POTEC →	+0.130	+3.321	<.001	.008	3	1
SCLC	PSG1 →	+0.082	+3.584	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ANXA13 by OR4C45 expression — SCLC

Explore this box plot interactively →