OR4C45

Across TCGA pan-cancer cohorts, OR4C45 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated OR4C45 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher OR4C45 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OR4C45 expression acts as an unfavorable survival marker.

LUSC, LIHC, and CESC are the cancer types where OR4C45 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	II,III,IV	0.079	0.750	<.001	108	view →
LIHC	OS	Tertile	All	0.136	0.779	<.001	108	view →
CESC	OS	Tertile	II,III,IV	0.146	0.759	.004	90	view →
READ	OS	Tertile	All	0.198	0.829	.001	72	view →
BLCA	DFS	Tertile	All	0.159	0.625	.016	45	view →
ACC	OS	Tertile	All	0.214	0.802	.002	45	view →
KIRC	DFS	Tertile	IV	0.127	0.630	.039	24	view →
LGG	DFS	Tertile	All	0.282	0.742	<.001	24	view →
SARC	DFS	Tertile	All	0.114	0.355	.006	24	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

OR4C45–LUSC (DFS)

Open the LUSC breakdown →