OR2Y1

Across TCGA pan-cancer cohorts, OR2Y1 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated OR2Y1 data layer compared with 4 for mutation status.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher OR2Y1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OR2Y1 expression acts as an unfavorable survival marker, although some lineages such as ESCA show a favorable association.

DLBC, SCLC, and ESCA are the cancer types where OR2Y1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	II,III,IV	0.172	0.949	<.001	54	view →
SCLC	DFS	Tertile	II,III,IV	0.247	0.797	.016	36	view →
ESCA	OS	Tertile	III,IV	0.756	0.351	.010	36	view →
KIRC	DFS	Tertile	IV	0.221	0.603	.046	18	view →
BLCA	DFS	Tertile	IV	0.122	0.469	.022	18	view →
LIHC	OS	Tertile	All	0.083	0.783	<.001	18	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
GBM	DFS	Tertile	All	0.076	0.292	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

OR2Y1–DLBC (OS)

Open the DLBC breakdown →