OR2T33

Across TCGA patient cohorts, OR2T33 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2T33-associated genes across cancer lineages are C-Raf, PDCD4, and JNK_pT183_Y185. Each is linked with OR2T33 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2T33-to-partner and partner-to-OR2T33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by OR2T33-low versus OR2T33-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2T33→partner) and Y-score (partner→OR2T33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.238	+2.815	.003	.036	3	2
UCEC	PDCD4 →	-0.615	-2.459	.006	.020	3	2
SKCM	JNK_pT183_Y185 →	-0.155	-3.169	.003	.017	3	2
UCEC	EGFR_pY1068 →	-0.331	-3.584	.006	.002	3	1
UCEC	GAPDH →	+0.534	+3.169	.039	.018	3	1
UCEC	PCNA →	+0.329	+3.584	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

C-Raf by OR2T33 expression — COAD

Explore this box plot interactively →