OR2T12

Across TCGA patient cohorts, OR2T12 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2T12-associated genes across cancer lineages are MSH6, Cyclin-B1, and 4E-BP1_pT70. Each is linked with OR2T12 in more than 4 cancer types. Because this analysis shows association rather than direction, both OR2T12-to-partner and partner-to-OR2T12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by OR2T12-low versus OR2T12-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2T12→partner) and Y-score (partner→OR2T12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MSH6 →	+0.521	+3.025	.010	.019	3	3
UCEC	Cyclin-B1 →	+0.865	+2.502	<.001	.002	1	5
COAD	4E-BP1_pT70 →	+0.132	+3.008	.033	.019	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.611	-2.489	<.001	.002	3	2
LUSC	eIF4E →	+0.180	+2.821	.023	.035	3	2
LUSC	Chk1 →	+0.236	+3.009	.027	.019	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

MSH6 by OR2T12 expression — COAD

Explore this box plot interactively →