OR2T11

Across TCGA patient cohorts, OR2T11 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible OR2T11-associated genes across cancer lineages are KLK5, C14orf177, and EDDM3B. Each is linked with OR2T11 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2T11-to-partner and partner-to-OR2T11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLK5 grouped by OR2T11-low versus OR2T11-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2T11→partner) and Y-score (partner→OR2T11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	KLK5 →	+0.647	+4.847	<.001	.009	3	1
SCLC	C14orf177 →	+0.137	+4.847	<.001	.009	3	1
SCLC	EDDM3B →	+0.206	+4.847	<.001	.009	3	1
SCLC	OR10J1 →	+0.085	+5.624	.001	.003	3	1
SCLC	CXorf66 →	+0.139	+5.624	<.001	.003	3	1
SCLC	UGT1A5 →	+0.072	+4.847	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

KLK5 by OR2T11 expression — SCLC

Explore this box plot interactively →