OR2S2

Across TCGA patient cohorts, OR2S2 mutation is significantly associated with the RNA expression of many other genes, with 304 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2S2-associated genes across cancer lineages are RNA5SP64, PDSS1P2, and RRM2P2. Each is linked with OR2S2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2S2-to-partner and partner-to-OR2S2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP64 grouped by OR2S2-low versus OR2S2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2S2→partner) and Y-score (partner→OR2S2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP64 →	+0.242	+4.566	<.001	.003	3	2
SKCM	PDSS1P2 →	+0.096	+3.294	<.001	.004	3	2
SKCM	RRM2P2 →	+0.173	+3.605	<.001	.008	3	2
SKCM	RN7SKP60 →	+0.136	+4.147	<.001	.008	3	2
SKCM	MTND4LP24 →	+0.102	+4.897	<.001	.002	3	2
UCEC	TOMM22 →	+0.610	+3.343	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 304 associations by consensus.

RNA5SP64 by OR2S2 expression — UCEC

Explore this box plot interactively →