OR2S2

Across TCGA pan-cancer cohorts, OR2S2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of OR2S2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where OR2S2 RNA is repressed in tumor relative to normal tissue. In most cancer types OR2S2 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LUSC, and KIRP are the cancer types where OR2S2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OR2S2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−0.037	.006	4	view →
LUSC	All	All	−0.014	.018	2	view →
KIRP	All	II,III,IV	+0.023	.043	1	view →
KIRC	All	II,III,IV	−0.007	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

OR2S2–COAD

Open the COAD breakdown →