OR2S2

Across TCGA patient cohorts, OR2S2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2S2-associated genes across cancer lineages are eEF2, eIF4G, and STAT3_pY705. Each is linked with OR2S2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2S2-to-partner and partner-to-OR2S2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by OR2S2-low versus OR2S2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2S2→partner) and Y-score (partner→OR2S2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.411	+3.169	.036	.020	3	1
UCEC	eIF4G →	+0.396	+3.169	.020	.020	3	1
UCEC	STAT3_pY705 →	-0.513	-2.999	<.001	.035	3	1
UCEC	TFRC →	+1.024	+3.169	<.001	.020	3	1
UCEC	ERK2 →	+0.282	+3.169	.007	.020	2	1
UCEC	Caspase-8 →	-0.327	-3.000	.017	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

eEF2 by OR2S2 expression — UCEC

Explore this box plot interactively →