OR2S2

Across TCGA cell cohorts, OR2S2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. CNS shows the largest number of these associations.

The most reproducible OR2S2-associated genes across cancer lineages are SSMEM1, NTSR2, and TEX55. Each is linked with OR2S2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2S2-to-partner and partner-to-OR2S2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSMEM1 grouped by OR2S2-low versus OR2S2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2S2→partner) and Y-score (partner→OR2S2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SSMEM1 →	+0.023	+3.707	.008	.009	3	1
LARGE_INTESTINE	NTSR2 →	+0.087	+3.793	<.001	.007	3	1
CNS	TEX55 →	+0.049	+5.321	<.001	.005	3	1
CNS	OR11H6 →	+0.021	+5.321	<.001	.005	3	1
CNS	FGF3 →	+0.040	+4.981	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SSMEM1 by OR2S2 expression — LARGE_INTESTINE

Explore this box plot interactively →