OR2M5

Across TCGA patient cohorts, OR2M5 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible OR2M5-associated genes across cancer lineages are INPP4B, GSK-3a-b_pS21_S9, and TSC1. Each is linked with OR2M5 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR2M5-to-partner and partner-to-OR2M5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by OR2M5-low versus OR2M5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2M5→partner) and Y-score (partner→OR2M5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	INPP4B →	-0.539	-3.700	<.001	.001	3	3
LUAD	GSK-3a-b_pS21_S9 →	-0.294	-2.000	.028	.009	3	2
LUAD	TSC1 →	-0.394	-3.584	.002	.002	3	2
LUAD	VHL →	-1.083	-3.459	<.001	.004	3	2
LUAD	Chk1 →	+0.235	+3.584	.005	.002	3	2
UCEC	EGFR →	-0.209	-3.459	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

INPP4B by OR2M5 expression — LUAD

Explore this box plot interactively →