OR2M4

Across TCGA patient cohorts, OR2M4 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2M4-associated genes across cancer lineages are PCNA, PRDX1, and NF2. Each is linked with OR2M4 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR2M4-to-partner and partner-to-OR2M4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by OR2M4-low versus OR2M4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2M4→partner) and Y-score (partner→OR2M4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.236	+1.700	.010	.044	3	3
UCEC	PRDX1 →	+0.213	+3.321	.015	.010	2	3
SKCM	NF2 →	+0.252	+2.807	.026	.003	3	2
SKCM	PDK1_pS241 →	+0.153	+3.033	.032	.017	3	2
SKCM	VHL →	-0.635	-2.115	.033	.018	3	2
UCEC	ERK2 →	+0.183	+2.222	.025	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PCNA by OR2M4 expression — UCEC

Explore this box plot interactively →