OR2M4

Across TCGA cell cohorts, OR2M4 mutation is significantly associated with the mutation status of many other genes, with 1,383 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR2M4-associated genes across cancer lineages are OPRM1, TSSK1B, and PPP1R3C. Each is linked with OR2M4 in more than 3 cancer types. Because this analysis shows association rather than direction, both OR2M4-to-partner and partner-to-OR2M4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRM1 grouped by OR2M4-low versus OR2M4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2M4→partner) and Y-score (partner→OR2M4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OPRM1 →	+5.087	+4.523	.006	.006	1	4
LUNG_NSCLC_LUAD	TSSK1B →	+5.772	+5.772	.002	.002	1	3
LUNG_NSCLC_LUAD	PPP1R3C →	+4.187	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	GTF3C4 →	+4.772	+5.339	.004	.004	1	3
LUNG_NSCLC_LUAD	PDGFC →	+4.187	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	FOXN3 →	+4.772	+5.339	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,383 associations by consensus.

OPRM1 by OR2M4 expression — LARGE_INTESTINE

Explore this box plot interactively →