OR2K2

Across TCGA patient cohorts, OR2K2 mutation is significantly associated with the RNA expression of many other genes, with 228 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR2K2-associated genes across cancer lineages are KIFC1, MIR181A1, and GAGE2E. Each is linked with OR2K2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2K2-to-partner and partner-to-OR2K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIFC1 grouped by OR2K2-low versus OR2K2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2K2→partner) and Y-score (partner→OR2K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	KIFC1 →	+0.592	+2.031	.004	.005	3	2
LUAD	MIR181A1 →	+0.589	+5.343	<.001	.006	3	2
HNSC	GAGE2E →	+0.095	+5.023	.002	.003	3	2
COAD	RNU6-964P →	+0.603	+4.354	.008	.007	3	2
SKCM	LRRC20 →	+0.692	+2.709	<.001	.003	3	2
SKCM	SNORD116-10 →	+0.098	+3.121	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 228 associations by consensus.

KIFC1 by OR2K2 expression — SKCM

Explore this box plot interactively →