OR2K2

Across TCGA pan-cancer cohorts, OR2K2 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated OR2K2 data layer compared with 1 for mutation status.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher OR2K2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OR2K2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and ESCA show a favorable association.

DLBC, KIRC, and LAML are the cancer types where OR2K2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Tertile	All	0.195	0.847	<.001	81	view →
KIRC	OS	Tertile	All	0.514	0.660	<.001	69	view →
LAML	DFS	Median	All	0.417	0.665	<.001	50	view →
LUAD	OS	Tertile	II,III,IV	0.453	0.130	.016	21	view →
OV	DFS	Tertile	IV	0.298	0.522	.003	20	view →
SCLC	DFS	Tertile	III,IV	0.137	0.756	.025	18	view →
MESO	OS	Tertile	IV	0.188	0.622	.021	18	view →
TGCT	OS	Tertile	All	0.855	0.989	.004	18	view →
SKCM	OS	Tertile	IV	0.415	0.861	.014	15	view →
ESCA	OS	Tertile	III,IV	0.641	0.343	.024	13	view →
THYM	OS	Quartile	III,IV	0.579	1.000	.015	12	view →
LUSC	OS	Tertile	All	0.846	0.659	.013	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

OR2K2–DLBC (DFS)

Open the DLBC breakdown →