Across TCGA patient cohorts, OR2H2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2H2-associated genes across cancer lineages are A-Raf_pS299, ACC1, and INPP4B. Each is linked with OR2H2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2H2-to-partner and partner-to-OR2H2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2H2→partner) and Y-score (partner→OR2H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.106	-3.169	.043	.018	3	1
UCEC	ACC1 →	+0.332	+2.820	.036	.035	3	1
UCEC	INPP4B →	-0.378	-3.169	.007	.018	3	1
UCEC	JNK2 →	+0.315	+3.196	<.001	.009	3	1
UCEC	MEK1 →	+0.442	+2.584	.005	.010	3	1
UCEC	Rab11 →	-0.130	-2.115	.040	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

OR2H2 survival (RNA) · tumor vs normal (RNA) · all OR2H2 data types