Across TCGA pan-cancer cohorts, OR2H2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of OR2H2’s most consistent transcriptional readouts.

The strongest signal is observed in cholangiocarcinoma (CHOL), where OR2H2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR2H2 is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

CHOL, KIRP, and UCEC are the cancer types where OR2H2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OR2H2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CHOL	All	All	+0.557	.002	4	view →
KIRP	All	All	+0.062	.006	4	view →
UCEC	All	III,IV	−0.208	.038	2	view →
LUSC	All	All	+0.087	.011	2	view →
BRCA	All	III,IV	−0.049	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: OR2H2 RNA expression & survival · all OR2H2 data types