OR2D3

Across TCGA patient cohorts, OR2D3 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2D3-associated genes across cancer lineages are MIG-6, p27_pT198, and YB-1_pS102. Each is linked with OR2D3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2D3-to-partner and partner-to-OR2D3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by OR2D3-low versus OR2D3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2D3→partner) and Y-score (partner→OR2D3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIG-6 →	+0.090	+1.820	.028	.016	3	2
UCEC	p27_pT198 →	+0.101	+2.321	.021	.034	3	2
UCEC	YB-1_pS102 →	-0.168	-2.459	.028	.019	3	2
UCEC	eIF4G →	+0.313	+2.999	.014	.035	3	1
UCEC	A-Raf_pS299 →	-0.137	-3.321	.005	.010	3	1
UCEC	FoxM1 →	+0.315	+2.321	.003	.006	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

MIG-6 by OR2D3 expression — UCEC

Explore this box plot interactively →