Across TCGA pan-cancer cohorts, OR2D3 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OR2D3’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where OR2D3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR2D3 is over-expressed in tumor.
LUSC and KIRC are the cancer types where OR2D3 tumor–normal differential expression is most reproducible.