OR2D2

Across TCGA patient cohorts, OR2D2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2D2-associated genes across cancer lineages are IGFBP2, JNK_pT183_Y185, and Ku80. Each is linked with OR2D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2D2-to-partner and partner-to-OR2D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by OR2D2-low versus OR2D2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2D2→partner) and Y-score (partner→OR2D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.780	-3.169	.005	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.168	-2.102	.022	.019	3	1
UCEC	Ku80 →	+0.214	+1.598	.038	.044	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.434	-2.102	.027	.019	3	1
UCEC	Rab25 →	-0.284	-2.115	.049	.019	3	1
UCEC	Annexin-1 →	+0.523	+2.189	.023	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

IGFBP2 by OR2D2 expression — UCEC

Explore this box plot interactively →