OR2D2

Across TCGA cell cohorts, OR2D2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible OR2D2-associated genes across cancer lineages are GPR6, IFNK, and CARTPT. Each is linked with OR2D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2D2-to-partner and partner-to-OR2D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR6 grouped by OR2D2-low versus OR2D2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2D2→partner) and Y-score (partner→OR2D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR6 →	+0.039	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	IFNK →	+0.031	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	CARTPT →	+0.017	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	KCNK16 →	+0.027	+5.189	<.001	<.001	3	1
LUNG_SCLC	OR8B12 →	+0.036	+5.029	<.001	.006	3	1
LUNG_SCLC	OR8B8 →	+0.062	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

GPR6 by OR2D2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →