OR2B11

Across TCGA patient cohorts, OR2B11 mutation is significantly associated with the RNA expression of many other genes, with 1,068 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2B11-associated genes across cancer lineages are SEPHS1, ERMAP, and ADAMTS15. Each is linked with OR2B11 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR2B11-to-partner and partner-to-OR2B11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPHS1 grouped by OR2B11-low versus OR2B11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2B11→partner) and Y-score (partner→OR2B11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SEPHS1 →	+0.460	+3.207	.003	.009	3	3
UCEC	ERMAP →	-0.456	-3.405	.002	.005	3	2
UCEC	ADAMTS15 →	-1.241	-2.898	<.001	.001	3	2
UCEC	SLC25A33 →	+0.421	+2.330	.009	.003	3	2
SKCM	PRODH →	+0.547	+3.813	.009	<.001	3	2
SKCM	FOXM1 →	+0.796	+2.706	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,068 associations by consensus.

SEPHS1 by OR2B11 expression — SKCM

Explore this box plot interactively →