OR2A4

Across TCGA pan-cancer cohorts, OR2A4 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated OR2A4 data layer compared with 1 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher OR2A4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OR2A4 expression acts as an unfavorable survival marker, although some lineages such as STAD and CESC show a favorable association.

MESO, STAD, and THCA are the cancer types where OR2A4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	III,IV	0.069	0.580	<.001	108	view →
STAD	DFS	Median	III,IV	0.534	0.229	.006	98	view →
THCA	DFS	Tertile	III,IV	0.781	0.909	<.001	75	view →
KICH	OS	Tertile	III,IV	0.242	0.756	.012	75	view →
LIHC	DFS	Tertile	III,IV	0.116	0.383	<.001	60	view →
ACC	OS	Tertile	All	0.577	0.871	.002	34	view →
UCEC	DFS	Tertile	II,III,IV	0.557	0.762	.006	30	view →
KIRP	DFS	Quartile	III,IV	0.287	0.682	.004	21	view →
SCLC	DFS	Tertile	III,IV	0.137	0.546	.042	18	view →
CESC	OS	Tertile	All	0.923	0.774	.020	18	view →
SKCM	DFS	Tertile	IV	0.016	0.454	<.001	18	view →
TGCT	OS	Tertile	II,III,IV	0.802	1.000	.040	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

OR2A4–MESO (OS)

Open the MESO breakdown →