OR2A4

Across TCGA pan-cancer cohorts, OR2A4 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of OR2A4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OR2A4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR2A4 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

KIRC, KIRP, and PAAD are the cancer types where OR2A4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OR2A4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	+1.386	<.001	12	view →
KIRP	All	All	+0.062	.015	4	view →
PAAD	Male	All	+0.130	.022	2	view →
COAD	Female	II,III,IV	−0.064	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

OR2A4–KIRC

Open the KIRC breakdown →