Across TCGA patient cohorts, OR2A25 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2A25-associated genes across cancer lineages are Cyclin-B1, IRS1, and JNK_pT183_Y185. Each is linked with OR2A25 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR2A25-to-partner and partner-to-OR2A25 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2A25→partner) and Y-score (partner→OR2A25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.668	+2.321	.017	.035	3	3
UCEC	IRS1 →	+0.339	+2.321	.001	.035	3	2
UCEC	JNK_pT183_Y185 →	-0.202	-3.169	.017	.019	3	2
SKCM	PCNA →	+0.144	+1.415	.019	.041	3	2
UCEC	A-Raf_pS299 →	-0.135	-3.169	.025	.019	3	1
UCEC	MEK1 →	+0.519	+2.321	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

OR2A25 survival (RNA) · tumor vs normal (RNA) · all OR2A25 data types