Across TCGA pan-cancer cohorts, OR2A2 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated OR2A2 data layer compared with 6 for mutation status.
The strongest signal is observed in kidney chromophobe (KICH), where higher OR2A2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OR2A2 expression acts as an unfavorable survival marker, although some lineages such as LIHC and HNSC show a favorable association.
KICH, SKCM, and MESO are the cancer types where OR2A2 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.