OR2A1-AS1

Across TCGA pan-cancer cohorts, OR2A1-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of OR2A1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where OR2A1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types OR2A1-AS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where OR2A1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OR2A1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.644	<.001	11	view →
KIRC	Female	All	−0.502	<.001	9	view →
KICH	Female	All	−0.992	<.001	7	view →
COAD	Female	All	−0.774	<.001	7	view →
BRCA	All	III,IV	−0.811	<.001	6	view →
LUAD	Female	II,III,IV	−0.477	.003	6	view →
HNSC	All	II,III,IV	+0.357	.021	4	view →
LIHC	All	All	+0.318	.001	3	view →
CHOL	All	All	+0.890	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

OR2A1-AS1–THCA

Open the THCA breakdown →