OR1N2

Across TCGA patient cohorts, OR1N2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1N2-associated genes across cancer lineages are PCNA, ARID1A, and 14-3-3_zeta. Each is linked with OR1N2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1N2-to-partner and partner-to-OR1N2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by OR1N2-low versus OR1N2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1N2→partner) and Y-score (partner→OR1N2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCNA →	+0.141	+2.115	.045	.017	3	1
SKCM	ARID1A →	-0.107	-2.459	.029	.016	3	1
SKCM	14-3-3_zeta →	+0.207	+1.847	.006	.008	3	1
SKCM	Caveolin-1 →	-0.656	-2.459	.003	.017	3	1
UCEC	CD20 →	-0.151	-3.000	.046	.037	3	1
UCEC	Cyclin-B1 →	+0.895	+3.000	.005	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PCNA by OR1N2 expression — SKCM

Explore this box plot interactively →