OR1N1

Across TCGA cell cohorts, OR1N1 mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR1N1-associated genes across cancer lineages are FAM47C, C11orf97, and MMP20. Each is linked with OR1N1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1N1-to-partner and partner-to-OR1N1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM47C grouped by OR1N1-low versus OR1N1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1N1→partner) and Y-score (partner→OR1N1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1
SKIN	C11orf97 →	+0.047	+4.977	<.001	.007	3	1
BLOOD_Leukemia	MMP20 →	+0.063	+3.705	<.001	.007	3	1
BLOOD_Leukemia	KAAG1 →	+0.091	+3.855	<.001	.007	3	1
BLOOD_Leukemia	SERPINA12 →	+0.047	+4.060	<.001	.003	3	1
BLOOD_Leukemia	SPATA19 →	+0.018	+4.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

FAM47C by OR1N1 expression — SKIN

Explore this box plot interactively →