OR1M1

Across TCGA patient cohorts, OR1M1 mutation is significantly associated with the RNA expression of many other genes, with 1,721 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1M1-associated genes across cancer lineages are MYO5BP1, SEC13, and DAPK3. Each is linked with OR1M1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR1M1-to-partner and partner-to-OR1M1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO5BP1 grouped by OR1M1-low versus OR1M1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1M1→partner) and Y-score (partner→OR1M1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MYO5BP1 →	+0.098	+3.451	.003	.003	3	3
UCEC	SEC13 →	+0.445	+2.415	<.001	.003	3	3
UCEC	DAPK3 →	+0.467	+3.708	.002	<.001	3	3
UCEC	CDC34 →	+0.498	+3.724	.001	<.001	3	3
UCEC	ACD →	+0.479	+3.606	.001	.001	3	3
COAD	ADAM21P1 →	+0.093	+3.082	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,721 associations by consensus.

MYO5BP1 by OR1M1 expression — COAD

Explore this box plot interactively →