OR1M1

Across TCGA patient cohorts, OR1M1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1M1-associated genes across cancer lineages are FASN, FoxM1, and ACC_pS79. Each is linked with OR1M1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1M1-to-partner and partner-to-OR1M1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by OR1M1-low versus OR1M1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1M1→partner) and Y-score (partner→OR1M1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.456	+3.700	.013	.001	3	1
UCEC	FoxM1 →	+0.355	+2.584	.003	.011	3	1
UCEC	ACC_pS79 →	+0.463	+3.009	.004	.019	3	1
UCEC	JNK2 →	+0.261	+2.179	.004	.034	3	1
UCEC	Notch1 →	+0.192	+2.820	.003	.035	3	1
UCEC	p27_pT157 →	-0.060	-2.986	.027	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

FASN by OR1M1 expression — UCEC

Explore this box plot interactively →