OR1L8

Across TCGA patient cohorts, OR1L8 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1L8-associated genes across cancer lineages are STAT5a, JNK_pT183_Y185, and Annexin-1. Each is linked with OR1L8 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1L8-to-partner and partner-to-OR1L8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT5a grouped by OR1L8-low versus OR1L8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1L8→partner) and Y-score (partner→OR1L8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	STAT5a →	+0.514	+2.239	.005	.004	3	2
UCEC	JNK_pT183_Y185 →	-0.169	-2.102	.021	.019	3	2
UCEC	Annexin-1 →	+0.730	+3.341	.001	.005	3	2
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.583	+2.087	.001	.004	3	1
SKCM	MAPK_pT202_Y204 →	-0.351	-1.874	.018	.047	3	1
SKCM	mTOR →	+0.163	+1.874	.043	.047	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

STAT5a by OR1L8 expression — SKCM

Explore this box plot interactively →