OR1L6

Across TCGA patient cohorts, OR1L6 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1L6-associated genes across cancer lineages are 14-3-3_epsilon, PDCD4, and 4E-BP1_pT37_T46. Each is linked with OR1L6 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1L6-to-partner and partner-to-OR1L6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_epsilon grouped by OR1L6-low versus OR1L6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1L6→partner) and Y-score (partner→OR1L6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	14-3-3_epsilon →	+0.200	+2.186	.001	.034	3	2
UCEC	PDCD4 →	-0.825	-3.169	.001	.020	3	2
UCEC	4E-BP1_pT37_T46 →	-0.492	-2.986	.016	.035	3	2
UCEC	p62 Lck ligand →	+0.354	+3.169	.047	.020	3	1
UCEC	PDK1 →	+0.128	+3.013	.031	.018	3	1
SKCM	Heregulin →	+0.191	+2.820	.032	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

14-3-3_epsilon by OR1L6 expression — SKCM

Explore this box plot interactively →